THE SULLIVAN LAB
"The more intelligent the question we ask of Mother Nature,
the more intelligent will be her reply."
-- Sir Charles Sherrington
WHAT DO WE DO?
We study the regulation of gene expression in a fascinating protozoan parasite
called Toxoplasma gondii. Toxoplasma, a relative of the malarial parasite,
causes congenital birth defects, as well as opportunistic infection in AIDS,
cancer chemotherapy, and organ transplant patients. There is also recent evidence suggesting
that this parasite is linked to neurological disorders, such as schizophrenia and behavior modification.
We hypothesize that the proteins controlling gene expression at epigenetic, transcriptional,
and translational levels may represent novel drug targets to fight Toxoplasma
and other infectious diseases.
More about what we do can be read in this recent news article
Shown here are Toxoplasma parasites inside
human fibroblast cells
Follow the links below for more about...
News...
New publication: "Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii" (Eukaryotic Cell, 2012)
Dr. Sullivan received the 2012 Trustee Teaching Award
New publication: "PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium" (PNAS, 2012)
New publication: "Toxoplasma gondii Sis1-like J-domain protein is a cytosolic chaperone associated to HSP90/HSP70 complex" (Int J Biol Marcromol, 2012)
New publication: "Mechanisms of Toxoplasma gondii persistence and latency" (FEMS Microbiol Rev, 2011)
Congratulations to Christian Konrad on his AHA postdoctoral fellowship award (June, 2011)
Congratulations to Brad Joyce on his NIH NRSA postdoctoral fellowship award (March, 2011)
WHERE ARE WE?
Indiana University School of Medicine
Dept of Pharmacology & Toxicology
Dept of Microbiology and Immunology
635 Barnhill Drive, MS A-515
Indianapolis, IN 46202, USA
317-278-9017 (lab)
Click here for more about Indianapolis
CONTACT: wjsulliv@iupui.edu Last update: April, 2012